Tom R.
Phillips, Jean L. Jensen, Michael J. Rubino, Wen C. Yang and Ronaid D. Schultz.
Effects of Vaccines on the Canine Immune System Canadian
Journal of Veterinary Research, Vol. 53, 154-60
ABSTRACT The effects of several commercially available
polyvalent canine vaccines on the immune system of the dog were examined. The results
demonstrated that the polyvalent vaccines used in this study significantly suppressed the
absolute lymphocyte count and that most of the polyvalent vaccines significantly
suppressed lymphocyte response to mitogen, but had no effect on natural effector cell
activity, neutrophil chemiluminescence, nor antibody response to canine distemper virus.
The individual vaccine components from the polyval-ent vaccines when inoculated alone did
not significantly suppress the lymphocyte response to mitogen. However, when canine
distemper virus was combined with canine adenovirus type 1 or canine adenovirus type 2,
significant suppression in lymphocyte responsiveness to mitogen occurred. The results
indicate that interactions between canine distemper virus and canine adenovirus type I or
canine adenovirus type 2 are responsible for the polyvalent vaccine induced suppression of
lymphocyte responsiveness.
Dreesen
DW, Bernard KW, Parker RA, Deutsch AJ, Brown J. Immune complex-like
disease in 23 persons following a booster dose of rabies human diploid cell vaccine. Vaccine. 1986 Mar;4(1):45-9. PMID: 2938356 [PubMed - indexed for MEDLINE]
Romanov, V A, et al, "Role of Auto-immune Processes in the
Pathogenesis of Post-Vaccinal Lesions of the Nervous System", Oct 1977, Zh Mikrobiol
Epidemiol Immunobiol, 10:80-83.
Movsesiants, AA, et al, "Experimental Study of the Ability
of Different Strains of Vaccinia Virus to Induce Auto-Antibody Formation", Vopr
Virusol, May-Jun 1975; (3):297-302.
Negina, IuP, "Comparative Study of Auto-antibody Formation
Following Immunization With Different Types of Typhoid Vaccines", Zh Mikrobiol
Epidemiol Immunobiol, May 1980; (5):69-72.
Eibl
MM, Mannhalter JW, Zlabinger G. Abnormal T-lymphocyte
subpopulations in healthy subjects after tetanus booster immunization.N Engl J Med. 1984 Jan 19;310(3):198-9. No abstract available.PMID: 6228737
[PubMed - indexed for MEDLINE]
"As reported in a letter to the New
England Journal of Medicine in 1984, tests of T-lymphocyte subpopulations were done on 11
healthy adults before-and-after routine tetanus booster immunizations. Tests showed a
significant though temporary drop in T-helper lymphocytes (a class of white blood cells
which helps govern the immune system) in all of the subjects. Special concern rests in the
fact that in 4 of the subjects the T-helper cells fell to levels found in active AIDS
patients. (2) If this was the result of a single vaccine in healthy adults, it is sobering
to think of the consequences of the multiple vaccines (twenty-one at last count) routinely
given to infants with their immature systems during the first six months of life. However,
we can only speculate as to the consequences, as this test has never been
repeated."--Dr Buttram MD
