Mumps vaccine associated orchitis: Evidence supporting a
potential immune-mediated mechanism
Received 7 September 2009;
revised 21 December 2009;
accepted 6 January 2010.
Available online 17 January 2010.
Abstract
We report 3 cases of orchitis following vaccination with mumps–measles–rubella (MMR) vaccine, two with an onset within 3 days following vaccination. Orchitis is a common complication of mumps infection, particularly in post-pubertal males, and is also recognized as a very rare complication of mumps vaccination. These cases, discussed together with a comprehensive review of the existing literature regarding post-vaccine orchitis, highlight uncertainty regarding the pathogenesis of post-vaccine orchitis.