Drug induced aseptic meningitis (DIAM) citations
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Infections from drugs/poisons
Antibiotics: Amoxicillin, Trimethoprim, co-trimoxazole
(trimethoprim-sulfamethoxazole) Metronidazole.
Nonsteroidal anti-inflammatory: rofecoxib, Ibuprofen
Antibiotic & vaccine associated
paralytic Poliomyelitis (VAPP)
[Media UK, 1996] Meningitis clusters
linked to antibiotics (erythromycin)
Andrade
A, Hilmas E, Walter C. A rare occurrence of
trimethoprim/sulfamethoxazole (TMP/SMX)-induced aseptic meningitis in an older woman.J Am Geriatr Soc. 2000 Nov;48(11):1537-8. No abstract available.PMID: 11083344
[PubMed - indexed for MEDLINE]
Antonen
J, Hulkkonen J, Pasternack A, Hurme M. Interleukin 6 may be an important
mediator of trimethoprim-induced systemic adverse reaction resembling aseptic meningitis.Arch Intern Med. 2000 Jul 10;160(13):2066-7. No abstract available.PMID: 10888991
[PubMed - indexed for MEDLINE]
Alloway
JA, Mitchell SR. Sulfasalazine neurotoxicity: a report of aseptic
meningitis and a review of the literature.J Rheumatol. 1993
Feb;20(2):409-11. Review. No abstract available.PMID: 8097252 [PubMed - indexed for
MEDLINE]
Auxier
GG. Aseptic meningitis associated with administration of trimethoprim
and sulfamethoxazole.Am J Dis Child. 1990 Feb;144(2):144-5. No
abstract available.PMID: 2301318 [PubMed - indexed for MEDLINE]
Asmar
BI, Maqbool S, Dajani AS.Hematologic abnormalities after oral
trimethoprim-sulfamethoxazole therapy in children.Am J Dis Child.
1981 Dec;135(12):1100-3.PMID: 7315805 [PubMed - indexed for MEDLINE]
Barak S, Shaked Y, Bar ZG, Samra Y.Drug-induced post-surgical
haemorrhage resulting from trimethoprim-sulphamethoxazole. A case report.Int J Oral Maxillofac Surg. 1989 Aug;18(4):206-7.PMID: 2507668 [PubMed - indexed
for MEDLINE]
Berliner
S, Weinberger A, Shoenfeld Y, Sandbank U, Hazaz B, Joshua H, Rosen M, Pinkhas J.Ibuprofen
may induce meningitis in (NZB X NZW)F1 mice.Arthritis Rheum. 1985
Jan;28(1):104-7. No abstract available.PMID: 3966933 [PubMed - indexed for MEDLINE]
Barbot
F, Danan-Causanski S, Chaouat D, Thuong M.[Aseptic meningitis after
ranitidine treatment for systemic lupus erythematosus]Presse Med.
1999 Nov 13;28(35):1938. French. No abstract available.PMID: 10598151 [PubMed - indexed
for MEDLINE]
Ballas
ZK, Donta ST. Sulindac-induced aseptic meningitis.Arch Intern Med. 1982 Jan;142(1):165-6.PMID: 7053720 [PubMed - indexed for
MEDLINE]
Biosca
M, de la Figuera M, Garcia-Bragado F, Sampol G. Aseptic meningitis due
to trimethoprim-sulfamethoxazole.J Neurol Neurosurg Psychiatry.
1986 Mar;49(3):332-3. No abstract available.PMID: 3958749 [PubMed - indexed for MEDLINE]
Bouland
DL, Specht NL, Hegstad DR. Ibuprofen and aseptic meningitis.Ann Intern Med. 1986 May;104(5):731. No abstract available.PMID: 3963677 [PubMed
- indexed for MEDLINE]
Bonnel
RA, Villalba ML, Karwoski CB, Beitz J.Aseptic meningitis associated with
rofecoxib.Arch Intern Med. 2002 Mar 25;162(6):713-5.PMID: 11911727
[PubMed - in process]
Carrillo
F, Cubero A, Hernandez Gallego J, Jimenez Santana P. [Recurrence of
meningoencephalitis induced by cotrimoxazole]Rev Neurol. 1995
Jan-Feb;23(119):142-4. Spanish.PMID: 8548610 [PubMed - indexed for MEDLINE]
Capra
C, Monza GM, Meazza G, Ramella G.
Trimethoprim-sulfamethoxazole-induced aseptic meningitis: case report and literature
review.Intensive Care Med. 2000 Feb;26(2):212-4. Review.PMID:
10784311 [PubMed - indexed for MEDLINE]
Czerwenka
WM.Amoxicillin can induce aseptic meningitis.Arch
Intern Med. 1999 Dec 13-27;159(22):2746. No abstract available.PMID: 10597768 [PubMed -
indexed for MEDLINE]
Chaudhry
HJ, Cunha BA. Drug-induced aseptic meningitis. Diagnosis leads to quick
resolution. Postgrad Med. 1991 Nov 15;90(7):65-70. Review. PMID:
1946120 [PubMed - indexed for MEDLINE]
Corson
AP, Chretien JH. Metronidazole-associated aseptic meningitis.Clin Infect Dis. 1994 Nov;19(5):974. No abstract available.PMID: 7893894 [PubMed
- indexed for MEDLINE]
Czerwenka
W, Gruenwald C, Conen D. Aseptic meningitis after treatment with
amoxicillin.BMJ. 1999 Jun 5;318(7197):1521. No abstract
available.PMID: 10356006 [PubMed - indexed for MEDLINE]
Capra
C, Monza GM, Meazza G, Ramella G. Trimethoprim-sulfamethoxazole-induced
aseptic meningitis: case report and literature review.Intensive
Care Med. 2000 Feb;26(2):212-4. Review.PMID: 10784311 [PubMed - indexed for MEDLINE]
10597768 [PubMed - indexed for MEDLINE]
Carlson
J, Wiholm BE.Trimethoprim associated aseptic meningitis.Scand J Infect Dis. 1987;19(6):687-91.PMID: 3502034 [PubMed - indexed for
MEDLINE]
Durand
JM, Suchet L, Morange S, Michel B. Ranitidine and aseptic meningitis.BMJ. 1996 Apr 6;312(7035):886. No abstract available.PMID: 8611881 [PubMed -
indexed for MEDLINE]
Derbes SJ.Trimethoprim-induced aseptic meningitis.JAMA. 1984 Nov 23-30;252(20):2865-6. No abstract available.PMID: 6333524 [PubMed
- indexed for MEDLINE]
Durback
MA, Freeman J, Schumacher VR Jr.Recurrent ibuprofen-induced aseptic
meningitis: third episode after only 200 mg of generic ibuprofen.Arthritis
Rheum. 1988 Jun;31(6):813-5. No abstract available.PMID: 3382456 [PubMed - indexed for
MEDLINE]
Dang
CT, Riley DK.Aseptic meningitis secondary to carbamazepine therapy.Clin Infect Dis. 1996 Apr;22(4):729-30. Review. No abstract available.PMID:
8729227 [PubMed - indexed for MEDLINE]
Davis
BJ, Thompson J, Peimann A, Bendixen BH.Drug-induced aseptic meningitis
caused by two medications.Neurology. 1994 May;44(5):984-5. No
abstract available.PMID: 8190318 [PubMed - indexed for MEDLINE]
Ellison
DH. Hyperkalemia and trimethoprim-sulfamethoxazole.Am J Kidney Dis. 1997 Jun;29(6):959-62; discussion 962-5. No abstract
available.PMID: 9186085 [PubMed - indexed for MEDLINE]
Ewert
BH.Ibuprofen-associated meningitis in a woman with only serologic
evidence of a rheumatologic disorder.Am J Med Sci. 1989
May;297(5):326-7.PMID: 2785759 [PubMed - indexed for MEDLINE]
Escalante
A, Stimmler MM.Trimethoprim-sulfamethoxasole induced meningitis in
systemic lupus erythematosus.J Rheumatol. 1992
May;19(5):800-2.PMID: 1613713 [PubMed - indexed for MEDLINE]
Most reports of drug induced meningitis in systemic lupus erythematosus (SLE) have
implicated ibuprofen. We describe a 46-year-old woman with SLE who developed aseptic
meningitis abruptly after ingesting trimethoprim-sulfamethoxasole (TMP-SMX). This patient
had received TMP-SMX twice before; each was associated with increasingly severe reactions,
whose relationship with the use of TMP-SMX became apparent only in retrospect. A history
of medication use should be sought in all patients with meningitis who have an underlying
autoimmune disorder.
Figg WD.Aseptic meningitis associated with muromonab-CD3.DICP. 1991 Dec;25(12):1395. No abstract available.PMID: 1815441 [PubMed - indexed for MEDLINE]
Grimm
AM, Wolf JE.Aseptic meningitis associated with nonprescription ibuprofen
use.DICP. 1989 Sep;23(9):712. No abstract available.PMID: 2800589
[PubMed - indexed for MEDLINE]
Greenberg
GN.Recurrent sulindac-induced aseptic meningitis in a patient tolerant
to other nonsteroidal anti-inflammatory drugs.
South Med J. 1988 Nov;81(11):1463-4.PMID: 3187641 [PubMed - indexed
for MEDLINE]
Gordon
MF, Allon M, Coyle PK.Drug-induced meningitis.Neurology.
1990 Jan;40(1):163-4.PMID: 2296366 [PubMed - indexed for MEDLINE]
Meningitis is usually produced by an infectious agent, but there are multiple
noninfectious causes. Medications may produce both acute and recurrent meningitis. We
present a patient with 3 episodes of aseptic meningitis due to
trimethoprim-sulfamethoxazole, and then review the topic of drug-induced meningitis.
Giansiracusa
DF, Blumberg S, Kantrowitz FG.Aseptic meningitis associated with
ibuprofen.Arch Intern Med. 1980 Nov;140(11):1553. No abstract
available.PMID: 7436656 [PubMed - indexed for MEDLINE]
Gilroy
N, Gottlieb T, Spring P, Peiris O. Trimethoprim-induced aseptic
meningitis and uveitis.Lancet. 1997 Jul 12;350(9071):112. No
abstract available.PMID: 9228966 [PubMed - indexed for MEDLINE
Harrison
MS, Simonte SJ, Kauffman CA.Trimethoprim-induced aseptic meningitis in a
patient with AIDS: case report and review.Clin Infect Dis. 1994
Sep;19(3):431-4. Review.PMID: 7811861 [PubMed - indexed for MEDLINE]
Hanson
L.Ibuprofen-induced aseptic meningitis.J Tenn Med
Assoc. 1994 Feb;87(2):58. No abstract available.PMID: 8176914 [PubMed - indexed for
MEDLINE]
Horn
AC, Jarrett SW. Ibuprofen-induced aseptic meningitis in rheumatoid
arthritis. Ann Pharmacother. 1997 Sep;31(9):1009-11. PMID: 9296242
[PubMed - indexed for MEDLINE]
OBJECTIVE: To report a case of aseptic meningitis related to ibuprofen ingestion.
CASE SUMMARY: We discuss the case of a 56-year-old white man with a history of rheumatoid
arthritis and hypertension who became confused, nauseated, and began to vomit within 2
hours of the ingestion of ibuprofen. A diagnosis of ibuprofen-induced aseptic meningitis
was made based on the patient's physical and laboratory findings, the quick onset and
resolution of symptoms, and his medical history. DISCUSSION: Ibuprofen-induced aseptic
meningitis has been most frequently reported in patients with systemic lupus
erythematosus. However, there have been reports of this reaction in patients with other
underlying disease states. Various nonsteroidal antiinflammatory drugs have been reported
to cause this reaction, but ibuprofen is the most common offending agent. A drug-related
cause should be considered in any patient who presents with typical meningitis symptoms,
such as fever, headache, and stiff neck, that occur within hours of ingesting a drug.
CONCLUSIONS: Although persons with systemic lupus erythematosus appear to have an
increased risk for this type of reaction, the development of signs and symptoms in other
patients warrants the consideration of nonsteroidal antiinflammatory drugs as the cause of
aseptic meningitis.
Herlihy
TE. Phenazopyridine and aseptic meningitis. Ann
Intern Med. 1987 Jan;106(1):172-3. No abstract available. PMID: 3789573 [PubMed - indexed
for MEDLINE]
Hoppmann
RA, Peden JG, Ober SK. Central nervous system side effects of
nonsteroidal anti-inflammatory drugs. Aseptic meningitis, psychosis, and cognitive
dysfunction.Arch Intern Med. 1991 Jul;151(7):1309-13. Review.PMID:
2064481 [PubMed - indexed for MEDLINE]
Jick
H, Derby LE. Is co-trimoxazole safe?Lancet. 1995
Apr 29;345(8957):1118-9. No abstract available.PMID: 7715367 [PubMed - indexed for
MEDLINE]
Jurado
R, Carpenter SL, Rimland D. Case reports:
trimethoprim-sulfamethoxazole-induced meningitis in patients with HIV infection.Am J Med Sci. 1996 Jul;312(1):27-9.PMID: 8686726 [PubMed - indexed for MEDLINE]
Joffe
AM, Farley JD, Linden D, Goldsand G.
Trimethoprim-sulfamethoxazole-associated aseptic meningitis: case reports and review of
the literature.Am J Med. 1989 Sep;87(3):332-8. Review. No abstract
available.PMID: 2672812 [PubMed - indexed for MEDLINE]
Jacobsson
G, Elowson S. [Amoxicillin caused aseptic meningoencephalitis]Lakartidningen. 1999 Jan 20;96(3):201-2. Swedish. No abstract available.PMID:
10068320 [PubMed - indexed for MEDLINE]
Jolles
S, Sewell WA, Leighton C. Drug-induced aseptic meningitis:
diagnosis and management. Drug Saf. 2000 Mar;22(3):215-26.
Review.PMID: 10738845 [PubMed - indexed for MEDLINE]
Drug-induced aseptic meningitis (DIAM) has been reported as an uncommon adverse reaction
with numerous agents. It is a diagnosis of exclusion, and clinical signs and CSF findings
vary greatly. The body of evidence regarding DIAM is largely in the form of anecdotal case
reports and must be interpreted carefully bearing this in mind. The major categories of
causative agents are nonsteroidal anti-inflammatory drugs, antimicrobials, intravenous
immunoglobulin, intrathecal agents, vaccines and a number of other less frequently
reported agents. There appears to be an association between DIAM and connective tissue
disease, particularly systemic lupus erythematosus, and ibuprofen. There are 2 major
proposed mechanisms for DIAM. The first involves direct irritation of the meninges by
intrathecal administration of the drug, and the second involves immunological
hypersensitivity to the drug, most likely type III and type IV hypersensitivity.
Recognition and diagnosis of DIAM is important, as it is treatable by withdrawal of the
drug and recurrence is prevented. The outcome of DIAM is generally good, usually without
long term sequelae. This article describes the case reports of DIAM in the current
literature and discusses the diagnosis and management of this rare complication.
Joy ME, Michals ML, Canafax DM.Aseptic meningitis associated with muromonab-CD3 therapy.Clin Pharm. 1988 Oct;7(10):721. No abstract available.PMID: 3233895 [PubMed - indexed for MEDLINE]
Kaplan
BH, Nevitt MP, Pach JM, Herman DC.Aseptic meningitis and iridocyclitis
related to ibuprofen.Am J Ophthalmol. 1994 Jan 15;117(1):119-20. No
abstract available.PMID: 8291583 [PubMed - indexed for MEDLINE]
Kremer
I, Ritz R, Brunner F. Aseptic meningitis as an adverse effect of
co-trimoxazole.N Engl J Med. 1983 Jun 16;308(24):1481. No abstract
available.PMID: 6602292 [PubMed - indexed for MEDLINE]
Kindmark
CO, Carlsson U, Hedback B, Tove H. [Aseptic meningitis after
treatment with ibuprofen]Lakartidningen. 1987 Sep 2;84(36):2782-3.
Swedish. No abstract available.PMID: 3669815 [PubMed - indexed for MEDLINE]
Karlsson
M. [Symptoms of meningitis after trimethoprim treatment]Lakartidningen. 1986 Aug 6;83(32-33):2666-7. Swedish. No abstract available.PMID:
3747651 [PubMed - indexed for MEDLINE]
Katona
BG, Wigley FM, Walters JK, Caspi M.Aseptic meningitis from
over-the-counter ibuprofen.Lancet. 1988 Jan 2-9;1(8575-6):59. No
abstract available.PMID: 2891924 [PubMed - indexed for MEDLINE]
Lafferty TE, DeHoratius RJ, Smith JB.Aseptic meningitis as a
side effect of intravenous immune gammaglobulin.J Rheumatol. 1997
Dec;24(12):2491-2. No abstract available.PMID: 9415672 [PubMed - indexed for MEDLINE]
Levitz
RE, Dudley MN, Quintiliani R, Mullany LD, Nightingale CH.Cerebrospinal
fluid penetration of trimethoprim-sulphamethoxazole in two patients with gram-negative
bacillary meningitis.J Antimicrob Chemother. 1984 Apr;13(4):400-1.
No abstract available.PMID: 6609920 [PubMed - indexed for MEDLINE]
Lawson
JM, Grady MJ.Ibuprofen-induced aseptic meningitis in a previously
healthy patient.West J Med. 1985 Sep;143(3):386-7. No abstract
available.PMID: 4049858 [PubMed - indexed for MEDLINE]
Lewis
RJ. Fatal vasculitis following treatment with co-trimoxozole.Br J Rheumatol. 1995 Jan;34(1):84-5. No abstract available.
PMID: 7881847 [PubMed - indexed for MEDLINE]
Marinac JS. Drug- and chemical-induced aseptic
meningitis: a review of the literature. Ann Pharmacother. 1992
Jun;26(6):813-22. Review. PMID: 1611165 [PubMed - indexed for MEDLINE]
OBJECTIVE: The primary objective of this article is to provide readers with
case reports of drug- or chemical-induced aseptic meningitis (DCAM) described in the
medical literature. Background information regarding the classification of DCAM,
incidence, proposed mechanisms, associated risk factors, clinical management, and sequelae
is presented. DATA SOURCES: A MEDLINE search was used to identify pertinent background
literature and case reports of DCAM. DATA EXTRACTION: All case reports of DCAM involve
anecdotal information. A critical analysis of a causal relationship to the implicated drug
or chemical and the appearance of meningeal involvement is presented. Animal data are
included when pertinent. DATA SYNTHESIS: DCAM is a rare adverse event associated with
numerous agents. Patients present with a variety of clinical signs and symptoms and
laboratory findings of cerebral spinal fluid, when obtained, vary greatly. Most patients
fully recover without sequelae. CONCLUSIONS: Numerous drugs and chemicals have been
implicated in the medical literature as producing DCAM. Two proposed mechanisms of DCAM
have been theorized: a delayed hypersensitivity-type reaction and direct meningeal
irritation. The nonsteroidal antiinflammatory drugs, certain antibiotics, radiographic
agents, and muromonab-CD3 have been most frequently implicated. There appears to be an
association between the occurrence of the hypersensitivity-type reactions and underlying
collagen vascular or rheumatologic disease.
de
la Monte SM, Hutchins GM, Gupta PK.Aseptic meningitis, trimethoprim, and
Sjogren's syndrome.JAMA. 1985 Apr 19;253(15):2192. No abstract
available.PMID: 3871870 [PubMed - indexed for MEDLINE]
Muller
MP, Richardson DC, Walmsley SL. Trimethoprim-sulfamethoxazole induced
aseptic meningitis in a renal transplant patient.Clin Nephrol. 2001
Jan;55(1):80-4. Review.PMID: 11200873 [PubMed - indexed for MEDLINE]
Mifsud
AJ. Drug-related recurrent meningitis.J Infect.
1988 Sep;17(2):151-3.PMID: 3183406 [PubMed - indexed for MEDLINE]
Moris
G, Garcia-Monco JC. The challenge of drug-induced aseptic
meningitis. Arch Intern Med. 1999 Jun 14;159(11):1185-94. Review.
PMID: 10371226 [PubMed - indexed for MEDLINE]
Several drugs can induce the development of aseptic meningitis. Drug-induced
aseptic meningitis (DIAM) can mimic an infectious process as well as meningitides that are
secondary to systemic disorders for which these drugs are used. Thus, DIAM constitutes a
diagnostic and patient management challenge. Cases of DIAM were reviewed through a MEDLINE
literature search (up to June 1998) to identify possible clinical and laboratory
characteristics that would be helpful in distinguishing DIAM from other forms of
meningitis or in identifying a specific drug as the culprit of DIAM. Our review showed
that nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, intravenous
immunoglobulins, and OKT3 antibodies (monoclonal antibodies against the T3 receptor) are
the most frequent cause of DIAM. Resolution occurs several days after drug discontinuation
and the clinical and cerebrospinal fluid profile (neutrophilic pleocytosis) do not allow
DIAM to be distinguished from infectious meningitis. Nor are there any specific
characteristics associated with a specific drug. Systemic lupus erythematosus seems to
predispose to NSAID-related meningitis. We conclude that a thorough history on prior drug
intake must be conducted in every case of meningitis, with special focus on those
aforementioned drugs. If there is a suspicion of DIAM, a third-generation cephalosporin
seems a reasonable treatment option until cerebrospinal fluid cultures are available.
Meng MV, St Lezin M.Trimethoprim-sulfamethoxazole induced
recurrent aseptic meningitis.J Urol. 2000 Nov;164(5):1664-5. No
abstract available.PMID: 11025739 [PubMed - indexed for MEDLINE]
Maignen
F, Castot A, Falcy M, Efthymiou ML. [Drug-induced aseptic
meningitis]Therapie. 1992 Sep-Oct;47(5):399-402. Review.
French.PMID: 1299979 [PubMed - indexed for MEDLINE]
Aseptic meningitis is a very rare drug reaction involving non-steroidal antiinflammatory
agents (ibuprofen and sulindac), antibiotics (cotrimoxazole, trimethoprim, ciprofloxacin)
and miscellaneous drugs such as carbamazepine, human immune globulin and muromonab CD3.
Meningeal symptoms occur a few hours after drug intake and resolve without sequelae within
one or two days after drug withdrawal, mainly in young females with systemic lupus
erythematosus or mixed connective tissue disease. Biological findings and radiological
investigations are not suggestive of an infectious etiology or
rheumatological/neurological disturbances. Diagnosis is simple when recurrent episodes
coincide with drug ingestion.
Marinac
JS, Stanford JF. A severe hypersensitive reaction to
trimethoprim-sulfamethoxazole in a patient infected with human immunodeficiency virus.Clin Infect Dis. 1993 Jan;16(1):178-9. No abstract available.PMID: 8448304
[PubMed - indexed for MEDLINE]
Nair
J, Stacy M.Aseptic meningitis associated with salicylate overdose.Psychosomatics. 1993 Jul-Aug;34(4):372. No abstract available.PMID: 8351314
[PubMed - indexed for MEDLINE]
Oddou S, Molinier S, Coso D, Boulet JM, Gastaut JA, Bouabdallah R.
[Aseptic meningitis following treatment with immunoglobulins: physiopathological
and prognostic value of screening]Presse Med. 1995 May
27;24(19):916. French. No abstract available.PMID: 7638138 [PubMed - indexed for MEDLINE]
Parkes
AJ. Trimethoprim-sulfamethoxazole in the veteran population: is it still
being prescribed despite recognised complications?Med J Aust. 1995
Apr 17;162(8):445. No abstract available.PMID: 7746191 [PubMed - indexed for MEDLINE]
Poles
L, Theodor E.[Trimethoprim-sulphamethoxazole-induced meningitis]Harefuah. 1996 Jun 16;130(12):817-9, 879. Hebrew.PMID: 8885504 [PubMed - indexed
for MEDLINE]
Pisani
E, Fattorello C, Leotta MR, Marcello O, Zuliani C. Recurrence of
ibuprofen-induced aseptic meningitis in an otherwise healthy patient.Ital J Neurol Sci. 1999 Feb;20(1):59-62.PMID: 10933487 [PubMed - indexed for
MEDLINE]
Preminger-Shapiro
R, Nussinovitch M, Soen G, Varsano I. Aseptic meningitis: a
frequent side-effect of intravenous immunoglobulin?Eur J Pediatr.
1995 Oct;154(10):866-7. No abstract available.PMID: 8529693 [PubMed - indexed for MEDLINE]
Roel
JE, Gadano AC, Falcon JL. [Ketoprofen and aseptic meningitis] Medicina (B Aires). 1991;51(2):186. Spanish. No abstract available. PMID: 1820511
[PubMed - indexed for MEDLINE]
Peck
MG, Joyner PU.Ibuprofen-associated aseptic meningitis.Clin Pharm. 1982 Nov-Dec;1(6):561-5. No abstract available.PMID: 7185548 [PubMed
- indexed for MEDLINE]
Pisani
E, Fattorello C, Leotta MR, Marcello O, Zuliani C.Recurrence of
ibuprofen-induced aseptic meningitis in an otherwise healthy patient.Ital J Neurol Sci. 1999 Feb;20(1):59-62.PMID: 10933487 [PubMed - indexed for
MEDLINE]
Preminger-Shapiro
R, Nussinovitch M, Soen G, Varsano I.Aseptic meningitis: a frequent
side-effect of intravenous immunoglobulin?Eur J Pediatr. 1995
Oct;154(10):866-7. No abstract available.PMID: 8529693 [PubMed - indexed for MEDLINE]
Pashankar
D, McArdle M, Robinson A. Co-trimoxazole induced aseptic meningitis.Arch Dis Child. 1995 Sep;73(3):257-8.PMID: 7492171 [PubMed - indexed for MEDLINE]
Patey
O, Lacheheb A, Dellion S, Zanditenas D, Jungfer-Bouvier F, Lafaix C. A
rare case of cotrimoxazole-induced eosinophilic aseptic meningitis in an HIV-infected
patient.Scand J Infect Dis. 1998;30(5):530-1.PMID: 10066062 [PubMed
- indexed for MEDLINE]
Quinn
JP, Weinstein RA, Caplan LR.Eosinophilic meningitis and ibuprofen
therapy.Neurology. 1984 Jan;34(1):108-9.PMID: 6537831 [PubMed -
indexed for MEDLINE]
Ristikankare
M, Tarssanen L.[Trimethoprim-sulfadiazine-induced cholestasis]Duodecim. 1993;109(2):139-42. Finnish. No abstract available.PMID: 8013318
[PubMed - indexed for MEDLINE]
Rottach
K, Scheglmann K, Pfadenhauer K. Mollaret's meningitis: a new
aetiologic feature.Eur Neurol. 1996;36(3):172-3. No abstract
available.PMID: 8738949 [PubMed - indexed for MEDLINE]
Ruppert
GB, Barth WF. Tolmetin-induced aseptic meningitis.JAMA. 1981 Jan 2;245(1):67-8.PMID: 7431632 [PubMed - indexed for MEDLINE]
Rubin
SI, Toolan L, Halperin ML. Trimethoprim-induced exacerbation of
hyperkalemia in a dog with hypoadrenocorticism.J Vet Intern Med.
1998 May-Jun;12(3):186-8. No abstract available.PMID: 9595382 [PubMed - indexed for
MEDLINE]
Ruiz-Irastorza
G, Montejo M, Ituarte J, Aguirre C.[Prolonged cholestasis following
single dose of cotrimoxazole++]Rev Clin Esp. 1996
Dec;196(12):879-80. Spanish. No abstract available.PMID: 9132870 [PubMed - indexed for
MEDLINE]
River
Y, Averbuch-Heller L, Weinberger M, Meiner Z, Mevorach D, Schlesinger I, Argov Z.Antibiotic
induced meningitis.J Neurol Neurosurg Psychiatry. 1994
Jun;57(6):705-8. Review.PMID: 8006651 [PubMed - indexed for MEDLINE]
Rudy
BJ, Rutstein R. Aseptic meningitis from trimethoprim-sulfamethoxazole in
an HIV-infected adolescent.Pediatr Emerg Care. 1997
Jun;13(3):216-7.PMID: 9220510 [PubMed - indexed for MEDLINE]
Streiffer
RH, Hudson JG. Aseptic meningitis and trimethoprim-sulfamethoxazole.J Fam Pract. 1986 Oct;23(4):314. No abstract available.PMID: 3489810 [PubMed -
indexed for MEDLINE]
Sirvent
N, Monpoux F, Benet L, Mariani R. [Aseptic meningitis during
treatment with immunoglobulins] Arch Pediatr. 1996 Aug;3(8):830-1.
French. No abstract available. PMID: 8998543 [PubMed - indexed for MEDLINE]
Seaton
RA, France AJ. Recurrent aseptic meningitis following non-
steroidal anti-inflammatory drugs--a reminder.Postgrad Med J. 1999
Dec;75(890):771-2.PMID: 10567617 [PubMed - indexed for MEDLINE]
Scribner
CL, Kapit RM, Phillips ET, Rickles NM. Aseptic meningitis and
intravenous immunoglobulin therapy.Ann Intern Med. 1994 Aug
15;121(4):305-6. No abstract available.PMID: 8037414 [PubMed - indexed for MEDLINE]
Saha
H, Lumio J, Pasternack A. [Acute aseptic meningitis induced by
trimethoprim]Duodecim. 1988;104(4):257-61. Finnish. No abstract
available.PMID: 3168833 [PubMed - indexed for MEDLINE]
Spigset
O, Messner T.[Suppression of bone marrow after drug interaction]Lakartidningen. 1993 Jun 2;90(22):2138-40. Swedish. No abstract available.PMID:
8502067 [PubMed - indexed for MEDLINE]
Sutton JD, Prioleau MH, Wordell CJ, Francos GC.Aseptic meningitis associated with muromonab CD3 administration.DICP. 1989 Mar;23(3):257-8. No abstract available.PMID: 2497590 [PubMed - indexed for MEDLINE]
Tunkel
AR, Starr K.Trimethoprim-sulfamethoxazole-associated aseptic meningitis.Am J Med. 1990 Jun;88(6):696-7. No abstract available.PMID: 2346166 [PubMed -
indexed for MEDLINE]
Tonolli
I, Velut JG, Lafay V, Thomachot L, Gambini D, Frances Y.
[Cotrimoxazole-induced aseptic meningitis: two cases]Presse Med.
1998 Apr 18;27(15):716-7. French. No abstract available.PMID: 9767911 [PubMed - indexed
for MEDLINE]
Thilmann
AF, Mobius E, Thilmann RR, Topper R. [Recurrent aseptic meningitis
(Mollaret meningitis)--spontaneous and drug-induced origin]Fortschr
Neurol Psychiatr. 1991 Dec;59(12):493-7. German.PMID: 1774010 [PubMed - indexed for MEDLINE]
Watanakunakorn
C. Hyperkalemia and trimethoprim-sulfamethoxazole.Ann
Intern Med. 1996 Nov 1;125(9):778; discussion 779-80. No abstract available.PMID: 8929019
[PubMed - indexed for MEDLINE]
Wittmann
A, Wooten GF. Amoxicillin-induced aseptic meningitis.Neurology. 2001 Nov 13;57(9):1734. No abstract available.PMID: 11706130 [PubMed -
indexed for MEDLINE]
Weksler
BB, Lehany AM. Naproxen-induced recurrent aseptic meningitis.DICP. 1991 Nov;25(11):1183-4.PMID: 1763533 [PubMed - indexed for MEDLINE]
Wong
JG, Hathaway SC, Paat JJ, Paterson RW, Steele GH Jr. Drug-induced
meningitis. A case involving trimethoprim-sulfamethoxazole.Postgrad
Med. 1994 Nov 1;96(6):117-8, 121,124.PMID: 7971606 [PubMed - indexed for MEDLINE]
Drug-induced meningitis should be considered in differential diagnosis of
meningeal irritation in patients receiving therapy with anti-infective, nonsteroidal
anti-inflammatory, immunosuppressive, or other selected agents. This report describes a
case of aseptic meningitis associated with use of trimethoprim-sulfamethoxazole in a
patient without apparent underlying autoimmune disease. The patient recovered promptly
after the offending agent was withdrawn. No specific treatment other than symptomatic and
supportive care need be given. In all instances, however, infection must be excluded.
de
Weerdt CJ, van de Poll MA.[Aseptic meningitis after use of Amipaque]Ned Tijdschr Geneeskd. 1980 Oct 18;124(42):1783-4. Dutch. No abstract
available.PMID: 7432567 [PubMed - indexed for MEDLINE]
van
der Zwan A, van Dam JG.[Ibuprofen meningitis]Ned
Tijdschr Geneeskd. 1992 Aug 15;136(33):1613-4.Dutch.PMID: 1407096 [PubMed - indexed for
MEDLINE]